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Singh P, Vinikoor T, Sharma N, Nelson N, Prasadh S, Oiknine R, et al

The decision to continue, adjust, or discontinue therapy should be individualized based on the underlying cause of back pain and the overall benefit-risk assessment

These signals include: Minimal Side Effects: You have adjusted to the 0.25 mg dose and are not experiencing debilitating nausea or GI distress

Combined with potential GI side effects, this may lead to fluid and electrolyte loss, making intentional hydration more important

Farokhnia M, Tazare J, Pince CL, Bruns N 6th, Gray JC, Lo Re V 3rd, Fiellin DA, Kranzler HR, Koob GF, Justice AC, Vendruscolo LF, Rentsch CT, Leggio L