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The weight loss achieved by CagriSema (-20.4% at 68 weeks) is comparable to that reported with the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist tirzepatide (-20.9% with the 15-mg dose at 72 weeks in SURMOUNT-1) [14]

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Histidine also has properties that protect against oxidative stress and may play a role in tissue repair [2]

The activity of renal -lyase in human kidney was comparable to that of mouse, but was an order of magnitude lower than that in the rat (Green et al., 1990)