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doi: 10.1016/S0140-6736(22)01839-6

Serendipity and the discovery of novel compounds that restore mitochondrial plasticity

Your body is using a large amount of energy to heal, and post-surgical fatigue or dietary restrictions usually naturally limit your intake

We discovered that Diphenyleneiodonium chloride (DPI), an inhibitor of flavoprotein enzymes and mitochondrial complex I, synergizes with mitoquinone mesylate (MitoQ), a mitochondria-targeted antioxidant in 2D and 3D in vitro models of NB