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Th17 Polarization of Memory T H Cells in Early Arthritis: The Vasoactive Intestinal Peptide Effect

Succinate, a key intermediate of the TCA cycle, tends to accumulate in mitochondria under ischemic conditions when the electron transport chain slows due to reduced oxygen availability 54

These findings provide a basis for dynamic monitoring (such as tracking the proportion of RRM2 amplified subclones) and targeted intervention (such as combined ATF4 inhibitors or IL-6/JAK blockers) (Wei et al., 2021

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