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In a comparison of patients with HFpEF with and without pulmonary vascular disease, exercise uncovered a distinct pathophysiology in the former group: there was impaired blood flow through the lungs, subsequent right heart congestion, and ventricular interdependence that decreased stroke volume and prevented an increase in cardiac output during exercise [79]

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Nucleic Acids Res 37, D933D937, doi: 10.1093/nar/gkn823 (2009)