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Glutathione treats the inside

J Clin Invest 2014;124:4473-88.ArticlePubMedPMC 58

ZhouXDWangJLGuoDDJiang WW LiZKWangLet al

Transforming growth factor-1 (TGF-1) can induce the EMT phenotype in melanoma cells and upregulate the levels of GPX4 and SLC7A11, while gambogenic acid, a xanthone derived from traditional Chinese medicine Gamboge, can promote ferroptosis by inhibiting the SLC7A11/GPX4 pathway in melanoma cells stimulated by TGF-1