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Moreover, TDNPs have been verified to activate the Nrf2/HO-1 signaling pathway to promote the proliferation and migration of fibroblasts by improving their endogenous antioxidant capacity and reducing cell apoptosis [40]

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Current Pharmaceutical Design , 19 (1), 7683

For chemical synthesis, innovation is focused on reducing solvent volumes, finding greener reagent alternatives, and redesigning the process to be less wasteful (e.g, flow chemistry, microwave-assisted SPPS)