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For constipation management , NICE Clinical Knowledge Summary guidance suggests a stepwise approach: first optimising fluid and fibre intake (introduced gradually to avoid worsening bloating), then considering appropriate laxatives based on stool consistency

Safety Precautions There have also been concerns about the risk of thyroid tumors, including medullary thyroid carcinoma, based on animal studies

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Other areas - cognitive (Semax, Selank), growth hormone investigative axis (Ipamorelin, CJC-1295), metabolic GLP-1 / GIP investigative analogues - sit alongside the four anchors above