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PLoS Genet 7(8):e1002229 Lee JS, Kang JH, Lee SH, Hong D, Son J, Hong KM, Song J, Kim SY (2016) Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC

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Further, this analysis set up the directions for future trials to look for the standard dose achieving maximal efficacy with the lowest possible side effects

In the STEP and SURMOUNT trial programs, participants treated with semaglutide and tirzepatide respectively achieved average weight reductions of 15 to 22% of total body weight, losses that had previously been achievable only through bariatric surgery [8,9]