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[DOI] [PubMed] [Google Scholar] 114.Steigerwalt RW, Williams JA

Inflammatory Bowel Disease While the aetiology of IBDs remains to be elucidated, there are numerous studies which indicate that genetic abnormalities in barrier components or those involved in immune signalling pathways are likely to be involved in disease pathogenesis

10.2174/1381612811319190006 75 Jablonski-MomeniA.Korbmacher-SteinerH.Heinzel-GutenbrunnerM.JablonskiB.JaquetW.BottenbergP

One proposed mechanism is the activation of matrix metalloproteinase-9 by homocysteine, which leads to disruption of the blood-retinal barrier and increased vascular permeability in the retina [61]