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Retatrutide achieves superior weight loss through additive effects from three receptor pathways rather than maximizing a single pathway

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The specific mutants designed are as follows: for the Clathrin box, we introduced mutations K63E, I87D, Q89A and K98E (referred as the Cla mutant)

Lee S, Li M, Le GH, Teopiz KM, Vinberg M, Ho R, Au HCT, Wong S, Valentino K, Kwan ATH, Rosenblat JD, McIntyre RS (2024) Glucagon-like peptide-1 receptor agonists (GLP-1RAs) as treatment for nicotine cessation in psychiatric populations: a systematic review