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Glutamine reliance in cell metabolism

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1, 3 The antibodies against thyroperoxidase (anti-TPO), antithyroglobulin (anti-Tg) and more rarely TSH-stimulation blocking antibody (TSBAb), are positively correlated with an increased inflammatory reaction in the thyroid and with the development of Hashimotos disease

Here, they identified metformin (an anti-diabetic drug) as a therapeutic activator of FOXO3 (86)

Among them, NLRP3 inflammasomes are the most intensively investigated, commonly present in neutrophils, monocytes, dendritic cells, macrophages, and non-hematopoietic cells