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ATTAIN-1 (orforglipron, 72 weeks): Discontinuation due to AEs: 5.3-10.3% (orforglipron) vs 2.7% placebo Key characteristics: GI profile is broadly similar to injectable GLP-1 agonists despite oral route Nausea rates are comparable to tirzepatide The oral formulation does not appear to worsen GI tolerability relative to SC injection Safety profile described as "consistent with injectable GLP-1 medicines" Ecnoglutide# Ecnoglutide is a cAMP-biased GLP-1 receptor agonist developed by Sciwind Biosciences

The effect was more or less equivalent to silymarin (35 mg/kg) while some parameters showed better results than silymarin

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This stability can improve experimental consistency, making it easier to identify meaningful results and reducing variability in data