the field has since advanced to triple agonists like retatrutide
After 30 days or so, your prescriber will gradually increase the dose (e.g., 0.5 mg, 1 mg, 1.7 mg) every 4 weeks until reaching a maintenance dose (often 1.7 mg or 2.4 mg once weekly) based on how your body is responding to the medication
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GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), and tirzepatide (Mounjaro) work by slowing gastric emptying and activating receptors in the brainstem, which can trigger nausea and vomiting
Nasal sprays may achieve similar pharmacokinetics to injections by avoiding first-pass metabolism, potentially matching Wegovy's efficacy with improved tolerability