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2.15 Glutathione peroxidase (GSH-Px) The reaction mixture containing 50 mM potassium phosphate, 1 mM EDTA, cytosol sample, 10 mM GSH, GSSG reductase (2.4 U/mL) and 1.5 mM NADPH was incubated at 37C for 5 min, followed by the addition of tert-butylhydroperoxide

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Use of drugs that inhibit organic cation transporter 1 activity (including tricyclic antidepressants, citalopram, proton-pump inhibitors, verapamil, diltiazem, doxazosin, spironolactone, clopidogrel, rosiglitazone, quinine, tramadol and codeine) increased intolerance to metformin (72)