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Meanwhile, silymarin has poor water solubility and low bioavailability, and only 23%47% can reach the systemic circulation after oral administration which limits its activity, a silymarin-loaded liquid nanoemulsion could be useful to deliver poorly water-soluble silymarin with excellent hepatic protection by enhanced oral bioavailability via nanosized particles 211

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NAC increased the ratio of homo-arginine to asymmetric dimethylarginine (ADMA) - a nitric oxide (NO) synthase inhibitor - in maternal blood ( P 0.01)

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