Strict vegans/vegetarians: Limited dietary intake
[DOI] [PMC free article] [PubMed] [Google Scholar] 64.Du ZX, Zhang HY, Meng X, Guan Y, Wang HQ
While kojic acid is generally considered safer than hydroquinone, pregnant and breastfeeding women should consult their healthcare provider before use
It may be relevant when remodeling occurs under metabolic strain, including GLP-1 use, caloric deficit, chronic fatigue, or age-related NAD+ decline
Open questions in the GHK-Cu field include the specific cellular targets responsible for the broad transcriptomic effects, the relationship between the copper-delivery role and the direct peptide-only effects (if any), the comparative biology of GHK-Cu and related copper-peptides in defined cellular contexts, and the translation of cell-culture and animal-model findings to clinical-research endpoints under controlled study conditions