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Berkeley and Toronto: Ten speed Press, 339

Chaves et al

MOTS-c is best for people focused on longevity, energy optimization, and metabolic health, especially those who want to overcome age-related fatigue, weight gain, or insulin resistance

Despite their therapeutic advantages, these oral medications are linked to a variety of possible side effects, with liver damage being a significant concern for drugs such as methotrexate and acitretin (Yelamos & Puig 2015