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The likely reason behind it is believed to be activation of Aktcyclic AMP-responsive element binding protein 1-Brain-derived neurotrophic factor (Akt-CREBBDNF) pathway [198]

The NTS participates in controlling hypertension in response to leptin, and leptin administration into the NTS increases the renal sympathetic nervous activity [260]

Andres Splenser, MD, an endocrinologist at Memorial Hermann, who was not involved in this study, suggested that the link may have something to do with the relationship between mood and appetite, among other potential factors