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High-throughput sequencing was then performed on a MiSeq (Illumina) instrument, which revealed wild-type sequences for the BRAF, NRAS, KIT, TERT, GNAQ, and GNA11 genes

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Consistent with these biological effects, data from a large population-based cohort in Taiwan showed that initiation of GLP-1RAs, compared with insulin, was associated with a significantly lower incidence of HCC (HR = 0.47, 95% CI: 0.360.61) (Yang et al., 2024)

Metformin improves hepatic IRS2/PI3K/Akt signaling in insulin-resistant rats of NASH and cirrhosis