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This lipid overload can induce insulin resistance, which further enhances renal urate reabsorption by activating the urate transporter 1 (URAT1) and sodium-dependent anion cotransporters in the proximal renal tubules

This is why short-half-life secretagogues are favored for studying physiological pulsatile dynamics

This is the most commonly used approach, and its strategy is to modify the second N-terminal amino acid position (Ala8) to protect from degradation by DPP-4

U-100 markings can help compare syringe listings, but they should not be used to calculate or change a dose