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Results Celecoxib, as a strong NSAID, caused serious changes in the stomach, including histopathological images showing mucosal defects in the intestine and stomach ulcers

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Figure 10 In addition to the sulfonamides, e.g., 40 and 41 , the spiro-oxindole dihydroquinazolinone derivative 42 was identified in the screening campaign and subsequently a large series of related analogues were made, e.g., by applying rapid MW-assisted reactions and thereafter examined as IRAP inhibitors in bioassays (Figure 10)

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PubMed PMID: 1292918