For the exhaustion criteria, four subjects (15.4%) with exhaustion in the L-carnitine group changed to normal, while only one subject (4.2%) in the placebo group changed to normal in exhaustion criteria
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A 6-month, double-blinded, placebo-controlled trial for DPN patients demonstrated that oral ALA (600 mg twice daily) significantly improved neurological symptom scores (NSS), neurological disability scores (NDS), VAS, and VPT compared to placebo
10.1152/ajpheart.00625.2023 5 AltyJ.FarrowM.LawlerK
Gahl WA, Schneider JA, Thoene JG, Chesney R (1986) Course of nephropathic cystinosis after age 10 years