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Discouraging clinical read-through: The most advanced human program on the same HGF/c-Met hypothesis (a different molecule, fosgonimeton) failed its primary endpoint in the Phase 2/3 LIFT-AD Alzheimers trial [6] [7]

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LY is a triple agonist at the GCGR, GIPR, and GLP-1R in vivo To further characterize LY in vivo, multiple genetically modied mouse models were employed to assess target receptor engagement and functional contribution to nutrient and energy metabolism

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Stevenson, D