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GLP-1s can offer weight loss of more than 15% a substantial amount that could make a real difference to comorbidities associated with obesity, such as cardiovascular outcomes, Guirguis says

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The role of dorsomedial hypothalamus (DMH) glucagon-like peptide-1 receptor (GLP-1R) neurons regulating cognitive satiation can be likened to stepping on a vehicles brake in response to traffic signals - a preemptive action taken before reaching the actual stop goal, reflecting a feed-forward control mechanism

This describes the intended amount of tirzepatide, not instructions for administering it