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These lifestyle modifications are essential first steps, as they offer broad health benefits and carry minimal risk

Many individuals on GLP-1 therapies also have comorbidities such as hypertension, hyperlipidemia, or cardiovascular disease, with each requiring ongoing monitoring and intervention

207,208 In cancers, these pathways become dysregulated, often through ligand overexpression or mutations in key components (e.g., PTCH1 or SMO, in Hedgehog-driven malignancies such as basal cell carcinoma 209 and medulloblastoma 210 )

Enzymatic modification of low-density lipoprotein in the arterial wall: a new role for plasmin and matrix metalloproteinases in atherogenesis