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Depending on the value of the shape parameter , the upper limit of the 95% confidence interval (CI) for 1 demonstrates an increasing hazard over time (wear-out failure type), whereas the 95% CI includes 1 for , suggesting a constant hazard rate throughout the exposure period (random failure type)

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Notably, depletion of either microglia or T cells significantly blocks tau-induced neurodegeneration [164]

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