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A recent meta-analysis suggested that Se supplementation could lower TSH and TPOAb levels, but only in patients with HT not treated with levothyroxine [82], reassessing the role of selenium in the management of patients with chronic thyroid disease [83]

Semaglutide, a GLP-1 receptor agonist originally developed for type 2 diabetes management, has demonstrated significant weight loss effects in clinical trials, with patients losing an average of 15-22% of their body weight over 68 weeks

11,23 Several hypotheses have been put forward to account for this discrepancy