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ACS Biomater Sci Eng

Published February 8, 2021 - More info Glucagon-like peptide-1 (GLP-1) is an incretin hormone that potentiates glucose-stimulated insulin secretion

Although retatrutide's glucose-dependent mechanism of action is designed to reduce hypoglycaemia risk compared with agents such as sulphonylureas or insulin, the risk is not eliminated particularly when retatrutide is used alongside other glucose-lowering therapies

Like virtually all medications, incretin mimetics come with side-effects, leading some patients to abandon treatment

No doubt, these data will likely lead to an indication in the label for the treatment of knee osteoarthritis once approved." Kenneth Custer, PhD, Eli Lilly Executive VP "People with obesity and knee osteoarthritis often live with pain and restricted mobility, and may eventually require total joint replacement