65 Zhu et al 66 reported a unique case where a patient developed a painful nodule on the left lower quadrant of her abdomen in response to exenatide extended-release injections
X-ray crystallography revealed that each monomer consists of: An 8-bladed -propeller domain (residues 61-495, colored green), which contains two substrate anchoring residues, Glu205, Glu206 (colored cyan) An / hydrolase domain (residues 39-55 and 497-766, colored magenta), which contains three catalytic residues, Ser630, His740, Asp708 (colored orange) The domain organization of the DPP-4 dimer is shown in Figure-2 and a view of the enzyme active site is shown in the inset
Neither use case has phase III evidence
The gradual dose titration recommended in prescribing guidance aims to minimise gastrointestinal side effects by allowing the body time to adapt to the medication's effects on gut motility
Instead, encourage patients to stay mindful of their protein, fiber, and fluid intake