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In agreement with the two-hit hypothesis proposed for NLRP3 inflammasome activation [8], no changes were observed in the levels of any of the inflammasome-related proteins when cells were incubated with an NLRP3 inflammasome inducer, such as MSU (150 g/ml) [39], without priming with LPS (Fig

[DOI] [PubMed] [Google Scholar] De Paiva CS, Villarreal AL, Corrales RM, Rahman HT, Chang VY, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Pflugfelder SC

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