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The STEP UP trial, a Phase 3b study published in The Lancet Diabetes & Endocrinology in 2025, evaluated a 7.2 mg weekly injection dose in over 1,400 adults with obesity (BMI of 30 or higher) and without diabetes

Lactate is the end-product of anaerobic glycolysis and the rate of lactate production when erythrocytes are incubated with autologous plasma, glucose or other potential substrates has been measured in a wide range of Australian native species

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