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Department of Cell Biology and Molecular Genetics, University of Maryland, methylene blue has shown to be more effective than retinol and vitamin c in aiding the aging skin in appearing youthful working as a powerful antioxidant to fight of oxidative stress, while boosting collagen and elastin production to aid in reducing and preventing wrinkles

And crucially it's irreversible

Vitamin A-retinoic acid signaling regulates hematopoietic stem cell dormancy

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Wegovy cannot be used in patients with a personal or family history of MEN 2 (Multiple Endocrine Neoplasia Syndrome type 2) or medullary thyroid cancer (MTC)