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Over time, these internal and external factors add up, with signs of aging often appearing first on facial skin, including: Fine lines and wrinkles Dryness and rough patches Sagging or loss of firmness Uneven tone or texture Age spots and other pigmentation changes While these changes are natural, theyre not entirely out of your control

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Shibuya-Tayoshi S, Tayoshi S, Sumitani S et al (2008) Lithium effects on brain glutamatergic and GABAergic systems of healthy volunteers as measured by proton magnetic resonance spectroscopy