A study of the self-reported side effects of people taking GLP-1s, including semaglutide, found that insomnia was the most common psychiatric side effect, accounting for approximately 11.7% psych-related effects
Another ginsenoside, Ginsenoside F2, can downregulate pro-inflammatory cytokine genes ( Il1b , Tnf , and Il6 ) in high-fat mice and modulate liver X receptor (LXR)-related gene expression ( Srebf1 and Fasn) , improving lipid metabolism and inflammatory responses (Zhou et al., 2021)
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Pharmacovigilance studies indicate that GLP-1RAs, with the exception of albiglutide, demonstrate potential associations with pancreatic cancer risk, particularly evident in exenatide-treated patients who exhibit elevated cancer incidence rates
