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If a lymph node biopsy is performed and contains metastatic melanoma (i.e., not a nodal nevus or false positive isolated immunoreactive cells but dense clusters of atypical or mitotically active melanocytes in the subcapsular sinus or nodal parenchyma), there should be no more doubt about the malignant nature of the primary tumor draining to this node

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When that doesnt happen, trimethylamine builds up in your body, eventually seeping into your system so that your breath, sweat, saliva and pee smell like rotten fish