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As the most abundant intracellular antioxidant, reduced glutathione (GSH) functions not merely as a scavenger of reactive oxygen species (ROS), but as a pivotal modulator of redox-sensitive enzymatic activity, mitochondrial integrity, inflammatory signaling, and metabolic resilience and flexibility

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In AD, LTF has been identified as a key predictor of amyloid pathology (Tsatsanis et al., 2021) and also directly affects the amyloidogenic A secretory pathway