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IV infusions are generally considered safe when administered by qualified professionals

J Clin Endocrinol Metab (2006) 91:507682

2012) characterised this as still a genuinely controversial issue, acknowledging both the relative rarity of serious adverse events in monitored clinical populations and the legitimate uncertainty about unconstrained off-label long-term use

Although several cytosolic GSTs isoforms occur (at least 17 in humans), the only GST present in the mitochondria is the class kappa isoform (57)