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26 GLP-1 and effects on bone metabolism Several studies show that the GLP-1R is expressed in some bone cells, including osteoclasts and BMSCs, but appears to be absent in mature osteoblasts, indicating a complex role in bone homeostasis that is incompletely understood

Ca 2+ mobilization was measured as increase in fluorescence using Ensight Multimode Plate Reader (PerkinElmer, excitation wavelength 494 nm, emission wavelength 516 nm) and expressed as relative fluorescence units: RFU = (mean of 30 s after drug stimulation-baseline)/baseline

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El uso constante durante varias semanas o meses es fundamental para observar cambios notables