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In clinical trials, obese adults in the study lost an average of 12 to 13% of their body weight during a 68-week period, compared to only 2% to 4% weight loss for trial subjects who took the placebo

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First, an amino acid substitution at position 8 (alanine replaced with aminoisobutyric acid) provides resistance to DPP-4 degradation, the primary enzyme responsible for native GLP-1 breakdown

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It has been reported that the most important cause of mortality and morbidity after ruptured aneurysm is vasospasm 19