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Findings from this study showed that ICV infusion of leptin improved cardiac function after myocardial infarction (MI) in rats, an effect that seems to be mediated by the brain melanocortin 4 receprtos (MC4R) since the cardioprotective effect of ICV leptin infusion is lost in MC4R knockout rats and infusion of MC4R agonist in the brain recaptulates leptins cardioprotective effect post-MI

doi: 10.1016/j.ejphar.2015.04.045 7 OpieEL