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Oxidative modifications and consequent inhibition of PDHC activity is consistent with the increased rate of hydrogen peroxide formation and reduced complex V activity observed in children with autism given the increased vulnerability of this complex to oxidative and nitrative stress

Of note, some discuss high levels of oxidative stress markers as an independent factor of ASD etiology, rather than a result of antioxidant imbalance (Chauhan and Chauhan, 2006)

Polyunsaturated fatty acids (PUFAs), miR-3595 [114], miR-205 [115], and miR-224-5p [116] can reduce the expression of ACSL4

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However, some users have reported changes in menstrual cycles and other hormone-related symptoms during treatment