The scientists introduced two new cysteine amino acid residues into their antibodies - which they call THIOMABs - and conjugated drugs to these instead of relying on amino acids that were naturally present
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In PD, the essential degeneration process is influenced by several pathophysiological factors, including mitochondrial dysfunction, increased oxidative stress, inflammation, neurotrophic factor deficiency, impairment of the proteasome-autophagia process, and generation of -synuclein oligomers that form the Lewy bodies [2,3,4,5, 43, 44]
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