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The accumulation of vitamin B12 occurs mainly in the liver

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Hussain, J

What they found: NR is rapidly absorbed orally , peak at 30 minutes NR is converted to NAD+ in multiple tissues , liver, muscle, blood Plasma NAD+ rises 2 to 8 after a single dose Optimal dosing regimens: 100 to 1000 mg No accumulation of toxic metabolites Why it matters: This is the reference pharmacokinetic publication for NR and NMN