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However, it is now believed that while cell senescence initially acts as a robust barrier against tumor initiation, the subsequent accumulation of senescent cells can paradoxically promote cancer recurrence and cause damage to neighboring tissues

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Why Peter recommends earlier and more aggressive screening tests than guidelines suggest: colonoscopies, coronary imaging, PSA, Lp(a), and low-dose CT scans, and more [43:30]

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While renal dysfunction progresses, the most important indicators of oxidative stress are plasma F2-isoprostanes, 8-oxo-7,8-dihydro-2-deoxyguanosine, malondialdehyde (MDA), carbamylated proteins, advanced oxidation protein products, asymmetric dimethylarginine, and oxidized lipoprotein particles (138, 141, 142)