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Ganju and colleagues concluded, These results provide the first large-scale evidence supporting GLP-1RAs as a safe and potentially beneficial adjunct in Crohns disease management. They went on to note that prospective studies and guideline development are urgently needed to define their role in integrated IBD and metabolic care.

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PT-141 is a synthetic analog of alpha-MSH that activates melanocortin receptors (MC3R and MC4R) in the hypothalamus