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197,198 Interestingly, tripartite motif containing 21 (TRIM21) was shown to facilitate Lys27-linked UFD1 polyubiquitination and inhibit the interaction of UFD1 with p97/VCP, thus suppressing ERAD and activating the proapoptotic UPR

It is the only non-surgical anti obesity drug to be endorsed in this capacity

These are treatments for a chronic condition, and weight can return if the medication stops, so many people stay on them long-term