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Quality control Country of origin : Asia, Europe and North America How sourced : Cultivated and wild-harvested Risks : Adulteration with other species of Silybum and the use of synthetic colorants and depleted extracts Key marker compounds : Silymarin and flavonoids Milk thistle ( Silybum marianum ) contains flavanolignans, flavonoids, and fixed oils based principally on linoleic and oleic acid (19)

Lab and animal studies build on this as well, showing the extract reduces inflammatory signals, boosts a protein important for barrier health (filaggrin), and has anti-itch/antibacterial activity (including against C.acnes, the bacteria linked to breakouts)

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Natural products as modulators of Nrf2 signaling pathway in neuroprotection

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