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The following covariates were adjusted in the model: child sex, delivery type, parity, gestational age, birth weight, maternal age, maternal marital status, prenatal smoking, prenatal alcohol use, intrauterine inflammation, preeclampsia, diabetes mellitus, maternal stress, estimated cell-type proportions (CD4 + T cells, CD8 + T cells, B cells, monocytes, granulocytes, natural killer cells and nucleated red blood cells) and surrogate variables

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Allergic reaction is characterized by the excessive activation of mast cells and basophils, leading to release various mediators such as histamine and an array of cytokines [107]