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The potential main mechanism responsible for SGLT2-i reno-protective properties probably resides in TGF activation and glomerular hyperfiltration reduction
10.3389/fphys.2024.1411218
McCall McPhereson: Welcome to the Dr
A lot of people worry about self-injecting or about the side effects of GLP-1, like digestive issues
Key Findings from the Clinical Trial The study, led by Christian Hendershot at USC's Institute for Addiction Science, showed that weekly injections of semaglutide compared to placebo: Reduced alcohol cravings significantly Decreased drinking quantity overall Lowered the frequency of heavy drinking days What makes these results particularly exciting is that the magnitude of semaglutide's effects appeared potentially greater than what is typically seen with existing FDA-approved medications for alcohol use disorder, even though the drug was only administered at the lowest clinical doses
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